This study aimed to determine the factors influencing the enrollment migration of Senior High School students in one of the Higher Education Institution (HEI), in Negros Island, Central Philippines in terms of tracks and strands, financial capacity and family support, school policies and school facilities. Moreover, this study aimed to find out whether or not significant difference exist in the following areas when grouped and compared according to age, sex, average monthly family income and school category. This study made use of descriptive research design with 286 students as respondents. Results of the study shows that the degree of influence of factors in enrollment migration of SHS students according to the aforementioned areas revealed with “high” results. Comparative analysis revealed that there is no significant difference in the degree of influence of factors in enrollment migration of respondents in the area of chosen track and strands, financial capacity and family support according to variables. While in the area of school policies there is a significant difference in terms of age. Further, in the area of school facilities there is a significant difference in terms of age and school category. Results of this study calls for the students that they should be guided accordingly as to what they really want to pursue in their future career for there are so many selections that will best fit to their interests and skills. Admission’s office must clearly explain to the students what the different offerings are available in the institution, what they will learn in a specific strand, what program they could possibly enroll in college and what are the possible career they can land into after graduation. Parents should support their children in their journey in school not only financially but most importantly morally. The persons in charge such as guards in the specific area should be firm in implementing the rules, yet in a nice way.